Multinutrient supplement as treatment: literature review and case report of a 12-year-old boy with bipolar disorder From: Ohio State University Date: 2009 August Authors: Frazier EA, Fristad MA, Arnold LE Journal: Journal of Child and Adolescent Psychopharmacology 19(4):453-60 Participants: 12-year-old boy (‘‘John’’)                    • During six years of conventional treatment (ages 6-12),                       no medication, alone or in combination, had maintained                       a desirable mood balance or consistent improvement in John’s functioning Disorder: Bipolar disorder-not otherwise specified (BP-NOS) – age 6               Bipolar I disorder (BP-I), mixed, with psychotic features – age 10               Generalized anxiety disorder (GAD) – age 8               Obsessive-compulsive disorder (OCD) – age 10 Design:Case study              • Titrated off all psychotropic medications in 19 days              • Treated with EMPowerplus for 14 months Results: “All diagnoses fully remitted”               EMPowerplus gave John a much better outcome than any previous treatment:                 • Hallucinations ceased                 • Anxiety decreased                 • Compulsions decreased                 • Impulsivity and fidgeting decreased substantially                 • Night terrors ceased; John slept throughout the night                 • Functioning corrected                     o at home – remained calm and playful; appeared ‘‘clear, slowed down, peaceful, settled, and happy”                     o with schoolwork – remained focused and efficient                     o with peers – began interacting more appropriately; maintained friendships